VERAPAMIL HYDROCHLORIDE

VERAPAMIL HYDROCHLORIDE
PRODUCT IDENTIFICATION
CAS NO.	52-53-9 152-11-4 (HCl)
EINECS NO.	200-145-1 205-800-5 (HCl)
FORMULA	C₂₇H₃₈N₂O₄^.HCl
MOL WT.	491.06
TOXICITY	Oral Rat LD50: 163mg/kg
H.S. CODE	2926.90.1400
SYNONYMS	Verapamil; Vasolan; Verapamil; Verapamilo; Verapamilum;
(RS)-2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl]-(methyl)amino}- 2-prop-2-yl pentanenitrile5-((3,4-Dimethoxyphenethyl)methylamino)-2-( 3,4-dimethoxyphenyl)-2- isopropylvaleronitrile; alpha-(1-Methylethyl)-alpha-(3-((2-(3,4-dimethoxyphenyl)ethyl)methylamino) propyl)-3,4-dimethoxybenzeneacetonitrile; Dexverapamil; Dilacoran; Falicard; Finoptin; Iproveratril; Isoptimo; Isoptine; Lekoptin; R,S-Verapamil; alpha-((N-Methyl-N-homoveratryl)-gamma- aminopropyl)- 3,4-dimethoxyphenyl acetonitrile; alpha-(3-((2-(3,4-Dimethoxyphenyl)ethyl)- methylamino) propyl) -3, 4-dimethoxy-alpha-(1-methylethyl) benzeneacetonitrile; alpha-Isopropyl-alpha-((N-methyl-N-homoveratryl)-gamma- aminopropyl)-3,4-dimethoxy phenylacetonitrile; DL-Verapamil; Other RN: 7482-85-1, 56949-77-0, 1007128-78-0
SMILES	c1([C@@](CCC[N@@](CCc2cc(c(OC)cc2)OC)C)(C(C)C)C#N) cc(c(OC)cc1)OC
CLASSIFICATION	Anti-arrhythmia agent, Calcium channel blocker, Cardiovascular agent, Vasodilator,
EXTRA NOTES	A calcium channel blocker that is a class IV anti-arrhythmia agent.
PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE	white crystalline powder
MELTING POINT	245 - 255 C
BOILING POINT
SPECIFIC GRAVITY
SOLUBILITY IN WATER	Soluble
SOLVENT SOLUBILITY	Sparingly soluble in chloroform. Soluble in ethanol, isopropanol, acetone, ethyl acetate; freely soluble in methanol.
pH	4.5 - 6.5
VAPOR DENSITY
REFRACTIVE INDEX
NFPA RATINGS	Health hazard: 1, Fire: 0, Reactivity Hazard: 0
AUTOIGNITION
FLASH POINT
STABILITY	Stable under normal conditions. Photosensitive
EXTERNAL LINKS & GENERAL DESCRIPTION
Wikipedia Linking Google Scholar Search Drug Information Portal (U.S. National Library of Medicine) - Verapamil http://www.sigmaaldrich.com/ α₁-adrenoceptor antagonist; L-type calcium channel blocker. Blocks L-type Ca²⁺ channels in smooth and cardiac muscle, induces apoptosis of human primary and metastatic colon adenocarcinoma cells in vitro. Drug resistance reversal agent acting on Pgp, e.g. decrease renal tubule elimination of digoxin. Increases basal ATPase activity of Pgp. Substrate of Cyp3A4 and CYP2C6. http://www.inchem.org/ Paroxysmal supraventricular tachycardia (PSVT): Verapamil is the drug of choice for prevention and treatment of PSVT. Angina: Verapamil has been shown to be effective in the treatment of angina pectoris. Hypertension: Verapamil may be used as an alternative treatment for mild or moderate hypertension. Verapamil seems to be as effective as nifedipine or nicardipine and does not produce reflex tachycardia. There is no contraindication in patients with bronchospastic diseases. http://bipolar.about.com/ Verapamil is readily available in generic form for a reasonable price. Dr. Jim Phelps of PsychEducation.org reports that he had no success using verapamil until Dr. Steve Dubovsky, who had done extensive research on verapamil for bipolar disorder, told him it was necessary to use the non-slow-release version. Using that version, he says he is "pretty sure" he has seen people respond to it. A study of 37 women by Wisner, et al, showed a 94 percent response rate for mania, but there was far less response for depression. The researchers concluded, "A definitive randomized clinical trial [of verapamil] for patients with bipolar disorder is compelling and urgently needed."
SALES SPECIFICATION
APPEARANCE	white to slightly yellow crystalline powder
IDENTIFICATION	passes Test A, B
ASSAY	98.5 ~ 101.5%
SPECIFIC ROTATION	+127° ~ +134°
MELTING POINT	245 ~ 255 C
IMPURITY	Individual impurity: 0.5% max Total impurity: 1.5% max
LOSS ON DRYING	0.5% max
SULPHATED ASH	0.1% max
TRANSPORTATION
PACKING
HAZARD CLASS	6.1 (Packing Group: III)
UN NO.	2811
SAFETY INFORMATION
GHS
SIGNAL WORD	Danger
PICTOGRAMS
HAZARD STATEMENTS	H301: Toxic if swallowed H330: Fatal if inhaled H311: Toxic in contact with skin
PRECAUTIONARY STATEMENTS	P301 + P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician P280: Wear protective gloves/protective clothing/eye protection/face protection P312: Call a POISON CENTER or doctor/physician if you feel unwell P302 + P350: IF ON SKIN: Gently wash with plenty of soap and water P310: Immediately call a POISON CENTER or doctor/physician P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing
EC DIRECTIVES
HAZARD CODES	T Toxic
RISK PHRASES	23/24/25: Toxic by inhalation, in contact with skin and if swallowed.
SAFETY PHRASES	36/37/39: Wear suitable protective clothing, gloves and eye/face protection. 45: In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
PRICE INFORMATION